34 articles - From Friday Jun 24 2022 to Friday Jul 01 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Ann Rheum Dis |
Developing guidelines for ultrarare rheumatic disorders: a bumpy ride. When it comes to the realm of ultrarare diseases, there are few physicians who are familiar with a disease, and there is a scarcity of literature. In this viewpoint, we describe challenges from the methodological perspectives that occurred during the process of developing recommendations for autoinflammatory disorders with the goal of finding solutions that facilitate the development of guidelines for ultrarare diseases in the future. |
| Rheumatology (Oxford) |
meta-analyses and systematic reviews
| Rheumatology (Oxford) |
A Genomic Meta-Analysis of Clinical Variables and Their Association with Intrinsic Molecular Subsets in Systemic Sclerosis. We identified multiple statistically significant differences in baseline demographics between the intrinsic subsets which may represent underlying features of disease pathogenesis (e.g. chronological stages of fibrosis) and have implications for treatments that are more likely to work in certain SSc populations. |
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-a-mediated ERK1/2 and JAK-STAT1 pathways. Our results suggest that ABCs contribute to the pathogenesis of RA by inducing the activation of FLS via TNF-a-mediated ERK1/2 and JAK-STAT1 pathways. |
Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component. Our multi-trait and cross-population study should elucidate complex pathogenesis shared components across autoimmune and allergic diseases. |
| Arthritis Care Res (Hoboken) |
Adolescents' and Young Adults' Recommendations for Implementing Healthcare Transition in Rheumatology: A Mixed Methods Study. Incorporating patient perspectives into research and clinical practice is an opportunity to strengthen educational programs. AYAs emphasized the importance of gaining independence and becoming empowered through the healthcare transition process with structured support from their rheumatology teams. |
Longitudinal Characterization of Vascular Inflammation and Disease Activity in Takayasu's Arteritis and Giant Cell Arteritis: A single-center prospective study. Disease activity in GCA and TAK is common throughout the disease course. Patterns of vascular PET activity at diagnosis and later in disease differ between GCA and TAK. |
| Arthritis Res Ther |
Comparison of developing tuberculosis following tumor necrosis factor inhibition and interleukin-6 inhibition in patients with rheumatoid arthritis: a nationwide observational study in South Korea, 2013-2018. The incidence of TB was not significantly different among biologic drugs in the current era, except for infliximab in patients who were not treated for LTBI. Treatment of LTBI might alleviate the drug-specific risk of TB in patients with RA. |
Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats. These results suggested that DL cycle dampened the arthritis and promoted bone resorption and bone mass loss. DL cycle affects bone turnover by regulating osteoclast production in osteoarthritic rats. |
Extracellular matrix protein turnover markers are associated with axial spondyloarthritis-a comparison with postpartum women and other non-axial spondyloarthritis controls with or without back pain. Biomarkers of type I, IV, and VI collagen and biomarkers of inflammation showed an altered turnover in patients with axSpA compared with the non-axSpA control groups. Such biomarkers may be useful in combination with MRI or independently to separate patients with axSpA from other back pain conditions. |
Improved skeletal muscle fatigue resistance in experimental autoimmune myositis mice following high-intensity interval training. HIIT improves fatigue resistance in a SAM mouse model, and this can be explained by the restoration of mitochondria oxidative capacity via inhibition of the ER stress pathway and PGC-1a-mediated mitochondrial biogenesis. |
Long-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada. Objectives To estimate associations between fine particulate matter (PM , but no relationships with ozone. Additional studies are needed to better understand interplays between the many constituents of air pollution and rheumatic diseases. |
Minimal disease activity (MDA) in patients with recent-onset psoriatic arthritis: predictive model based on machine learning. A key objective in the management of PsA should be control of pain, which is not always associated with inflammatory burden, and the establishment of measures to better control the various domains of PsA. |
Neutrophil activation in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis and large-vessel vasculitis. Circulating fMET appears to propagate neutrophil activation in AAV and LVV. Inhibition of fMET-mediated FPR1 signaling could be a novel therapeutic intervention for systemic vasculitides. |
Patient-reported outcomes of upadacitinib versus abatacept in patients with rheumatoid arthritis and an inadequate response to biologic disease-modifying antirheumatic drugs: 12- and 24-week results of a phase 3 trial. At week 12, UPA vs ABA treatment elicited greater improvements in key domains of physical functioning, pain, and general health and earlier improvements in HAQ-DI. Overall, more UPA- vs ABA-treated patients achieved =MCID in most PROs at al timepoints; however, not al differences were statistically significant. These data, however, highlight the faster response to UPA treatment. |
Safety and effectiveness of mepolizumab therapy in remission induction therapy for eosinophilic granulomatosis with polyangiitis: a retrospective study. This study suggested that the use of MPZ as remission induction therapy for severe EGPA might be safe and effective for controlling disease activity and reducing CS doses. |
| Arthritis Rheumatol |
| Rheumatology (Oxford) |
Guselkumab provides sustained domain-specific and comprehensive efficacy using composite indices in patients with active psoriatic arthritis. Treatment with guselkumab provided robust and sustained benefits across multiple PsA domains through 1 |
Immunosuppressive treatments selectively affect the humoral and cellular response to SARS-CoV-2 in vaccinated patients with vasculitis. Although patients with GCA apparently achieve a robust antibody seroconversion, there is a significant impairment of the neutralising activity. MTX significantly reduced al levels of the humoral response. Up to one third of patients do not develop a cellular immune protection in response to COVID-19 vaccination. |
Outcomes of children born to mothers with systemic lupus erythematosus exposed to hydroxychloroquine or azathioprine. There were no significant negative outcomes in children exposed to HCQ in pregnancy. AZA use was associated with increased reporting of childhood infection which warrants further study. |
Plenty of the editorials are available as full text through the publisher website using the provided link
Letters to the editors and authors’ replies
| Arthritis Res Ther |
Evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study. Immunohistochemical staining showed the presence of markers for synovial macrophages and fibroblast-like synoviocytes bordering a natural dorsal space next to the extensor tendon, suggesting the presence of a synovial lining. This implies that contrast-enhancement on MRI around extensor tendons at MCP-joints observed in early RA and pre-RA likely represents tenosynovitis and that inflammation of this synovial tissue is an early feature of RA. |
| Arthritis Rheumatol |
all remaining publications eg case reports, images of the month, etc…
| Ann Rheum Dis |
| Arthritis Care Res (Hoboken) |
| Arthritis Rheumatol |
| Rheumatology (Oxford) |